Search on: MITOGEN-ACTIVATED PROTEIN KINASES 
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Descriptor English:   Mitogen-Activated Protein Kinases 
Descriptor Spanish:   Proteínas Quinasas Activadas por Mitógenos 
Descriptor Portuguese:   Proteínas Quinases Ativadas por Mitógeno 
Synonyms English:   Kinases, Mitogen-Activated Protein
Mitogen Activated Protein Kinases
Protein Kinases, Mitogen-Activated  
Tree Number:   D08.811.913.696.620.682.700.567
D12.644.360.450
D12.776.476.450
Definition English:   A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES). 
See Related English:   MAP Kinase Signaling System
 
History Note English:   2000; for EXTRACELLULAR SIGNAL-REGULATED KINASES use CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1994-1999 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   34450 
Unique Identifier:   D020928 

Occurrence in VHL: 		 

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